4-1BB/CD137/TNFRSF9 (E2J5H) Rabbit Monoclonal Antibody (Alexa Fluor®488 Conjugate)#77564,Cell Signaling Technology (CST),77564

4-1BB/CD137/TNFRSF9 (E2J5H) Rabbit Monoclonal Antibody (Alexa Fluor®488 Conjugate) recognizes endogenous levels of total 4-1BB/CD137/TNFRSF9 protein.

Host

Rabbit

Reactivity

Mouse

Application

Flow Cytometry (Fixed/Permeabilized): 1:50 - 1:400 Flow Cytometry (Live): 1:50

Platform ID

BAB314438406

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

Name4-1BB/CD137/TNFRSF9 (E2J5H) Rabbit Monoclonal Antibody (Alexa Fluor®488 Conjugate)#77564
Cat. No.77564
Accession NumberP20334
Gene ID (Entrez)20334, 21942
HostRabbit
SensitivityEndogenous
ReactivityMouse
ApplicationFlow Cytometry (Fixed/Permeabilized): 1:50 - 1:400 Flow Cytometry (Live): 1:50
ImmunogenIgG
FormulationSupplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C.Do not aliquot the antibody. Protect from light. Do not freeze.
StorageSupplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C.Do not aliquot the antibody. Protect from light. Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

TNFRSF9 is a member of the tumor necrosis factor receptor superfamily (1,2). It is also called 4-1BB or CD137 (1, 2). 4-1BB/CD137/TNFRSF9 is expressed in activated CD4+ and CD8+ T cells, natural killer cells and dendritic cells (2-5). The ligand 4-1BBL/CD137L/TNFSF9 on antigen presenting cells binds to 4-1BB/CD137/TNFRSF9 and costimulates the activation of T cells (5). The binding of agonistic antibodies to 4-1BB/CD137/TNFRSF9 also leads to costimulation for T cell activation (5). Studies have shown the effectiveness of targeting 4-1BB/CD137/TNFRSF9 by its agonistic antibodies in cancer immunotherapy (6).Sun, Y. et al. (2002)Nat Med8, 1405-13.Wilcox, R.A. et al. (2002)J Clin Invest109, 651-9.Lin, W. et al. (2008)Blood112, 699-707.Wilcox, R.A. et al. (2002)J Immunol168, 4262-7.Melero, I. et al. (1997)Nat Med3, 682-5.Yonezawa, A. et al. (2015)Clin Cancer Res21, 3113-20.Alternate Names4-1BB; 4-1BB ligand receptor; A930040I11Rik; AA408498; AI325004; Cd137; CD137 antigen; CDw137; Ila; Ly6; Ly63; OTTMUSP00000010903; OTTMUSP00000010904; OTTMUSP00000010905; secreted CD137 antigen; T-cell antigen 4-1BB; Tnfrsf9; TNR9; Tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily, member 9

Synonyms

4-1BB; 4-1BB ligand receptor; A930040I11Rik; AA408498; AI325004; Cd137; CD137 antigen; CDw137; Ila; Ly6; Ly63; OTTMUSP00000010903; OTTMUSP00000010904; OTTMUSP00000010905; secreted CD137 antigen; T-cell antigen 4-1BB; Tnfrsf9; TNR9; Tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily, member 9

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