AAK1 Antibody#79832,Cell Signaling Technology (CST),79832

Adaptor-associated kinase 1 (AAK1) is a member of the Ark1/Prk1 family of serine/threonine kinases (1). AAK1 is enriched in synaptosomal preparations and modulates clathrin-dependent endocytosis, a process that is important in synaptic vesicle recycling and receptor-mediated endocytosis. AAK1, together with clathrin and clathrin-adaptor protein AP-2, forms a signaling complex at the cell membrane. AAK1-dependent phosphorylation of the mu-2 subunit of AP-2 enhances endocytosis efficiency (2,3). AAK1 is known to promote neuregulin/ErbB4 internalization to regulate neurotrophic signaling. Inhibition of AAK1 activity promotes cell surface expression of neuregulin/ErbB4, cell-bound neurotrophic factors that are implicated in brain development and synaptic plasticity (4).This product detects a SARS-CoV-2-related target for research into the mechanisms of the novel coronavirus that caused the COVID-19 pandemic.Conner, S.D. and Schmid, S.L. (2002)J Cell Biol156, 921-9.Flett, A. et al. (2005)Biochem Soc Symp, 65-70.Ricotta, D. et al. (2002)J Cell Biol156, 791-5.Kuai, L. et al. (2011)Chem Biol18, 891-906.Alternate NamesAAK1; Adaptor-associated kinase 1; AP2 associated kinase 1; AP2-associated protein kinase 1; DKFZp686F03202; DKFZp686K16132; FLJ23712; FLJ25931; FLJ31060; KIAA1048; MGC138170; MGC164568; MGC164570

AAK1; Adaptor-associated kinase 1; AP2 associated kinase 1; AP2-associated protein kinase 1; DKFZp686F03202; DKFZp686K16132; FLJ23712; FLJ25931; FLJ31060; KIAA1048; MGC138170; MGC164568; MGC164570