ACSS2 Antibody (YA645),MedChemexpress,HY-P80483

ACSS2 (Acetyl-CoA synthetase 2) is an enzyme that plays a crucial role in cellular metabolism by catalyzing the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate for ACSS2, and it efficiently converts acetate into acetyl-CoA. This enzymatic activity is pivotal for various cellular processes, including energy production, lipid metabolism, and histone acetylation. ACSS2 can also utilize propionate, albeit with a much lower affinity compared to acetate. The ability of ACSS2 to generate acetyl-CoA from short-chain fatty acids contributes to the pool of acetyl-CoA available for diverse metabolic pathways, emphasizing its importance in cellular energy homeostasis and the integration of metabolic signals.