AGO3 Antibody (YA3124),MedChemexpress,HY-P83379
AGO3 Antibody (YA3124) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AGO3.
Host
Rabbit
Reactivity
Human,Mouse,Rat
Application
WB
Conjugate
Non-conjugated
Platform ID
BAB707077896
Suppliers
(1)Biomedical Life sciences
MedChemexpress
Master of Bioactive Molecules
Contact
Tel: 609-228-6898
Fax: 609-228-5909
Email:
Specifications
2.Supplied in 10 mM PBS, pH 7.4, 150 mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Please refer to the lot-specific COA for specific buffer information.
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Scientific Background
AGO3, an integral player in RNA-mediated gene silencing (RNAi), exerts its regulatory role by binding to short RNAs, including microRNAs (miRNAs), and effectively repressing the translation of mRNAs that bear complementary sequences. Its involvement extends to the stabilization of small RNA derivatives, particularly small interfering RNAs (siRNAs), originating from processed RNA polymerase III-transcribed Alu repeats that harbor a DR2 retinoic acid response element (RARE) in stem cells. AGO3 is proposed to orchestrate the subsequent siRNA-dependent degradation of a specific subset of RNA polymerase II-transcribed coding mRNAs by recruiting an mRNA decapping complex, which includes EDC4. While possessing RNA slicer activity, AGO3 exhibits this cleavage function selectively, targeting RNAs with distinct 5'- and 3'-flanking sequences within the region of guide-target complementarity.
Synonyms
EIF2C3; Argonaute3; Argonaute 3; AGO3; EIF-2C 3; HAgo3; EIF2C 3; Protein argonaute-3
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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