AIRE antibody,Genetex,GTX04258

Host

Rabbit

Reactivity

Human, Mouse, Rat

Application

WB IHC-P

Conjugate

Unconjugated

Platform ID

BAB539165658

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameAIRE antibody
Cat. No.GTX04258
Gene ID (Entrez)326
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse, Rat
ConjugationUnconjugated
ApplicationWB IHC-P
ClonalityPolyclonal
Concentration1 mg/ml (Please refer to the vial label for the specific concentration.)
TargetAIRE
ImmunogenSynthetic peptide, corresponding to amino acids 101-150 of Human AIRE.
PurityPurified by antigen-affinity chromatographyFrom serum
Appearance/FormLiquid
FormulationPBS, 50% Glycerol,0.02% sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED). [provided by RefSeq, Jun 2012]

Synonyms

autoimmune regulator , AIRE1 , APECED , APS1 , APSI , PGA1

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