ALK (D5F3) Rabbit Monoclonal Antibody (Alexa Fluor^®700 Conjugate)#41039,Cell Signaling Technology (CST),41039

Anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor for pleiotrophin (PTN), a growth factor involved in embryonic brain development (1-3). In ALK-expressing cells, PTN induces phosphorylation of both ALK and the downstream effectors IRS-1, Shc, PLCγ, and PI3 kinase (1). ALK was originally discovered as a nucleophosmin (NPM)-ALK fusion protein produced by a translocation (4). Investigators have found that the NPM-ALK fusion protein is a constitutively active, oncogenic tyrosine kinase associated with anaplastic lymphoma (4). Research literature suggests that activation of PLCγ by NPM-ALK may be a crucial step for its mitogenic activity and involved in the pathogenesis of anaplastic lymphomas (5).A distinct ALK oncogenic fusion protein involving ALK and echinoderm microtubule-associated protein like 4 (EML4) has been described in the research literature from a non-small cell lung cancer (NSCLC) cell line, with corresponding fusion transcripts present in some cases of lung adenocarcinoma. The short, amino-terminal region of the microtubule-associated protein EML4 is fused to the kinase domain of ALK (6-8).Stoica, G.E. et al. (2001)J Biol Chem276, 16772-9.Iwahara, T. et al. (1997)Oncogene14, 439-49.Morris, S.W. et al. (1997)Oncogene14, 2175-88.Morris, S.W. et al. (1994)Science263, 1281-4.Bai, R.Y. et al. (1998)Mol Cell Biol18, 6951-61.Rikova, K. et al. (2007)Cell131, 1190-203.Takeuchi, K. et al. (2008)Clin Cancer Res14, 6618-24.Soda, M. et al. (2007) Nature 448, 561-6.Alternate NamesALK; ALK receptor tyrosine kinase; ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; anaplastic lymphoma receptor tyrosine kinase; CD246; CD246 antigen; mutant anaplastic lymphoma kinase; NBLST3

ALK; ALK receptor tyrosine kinase; ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; anaplastic lymphoma receptor tyrosine kinase; CD246; CD246 antigen; mutant anaplastic lymphoma kinase; NBLST3