ALPK1 Rabbit mAb,ABclonal,A24046

Reactivity

Mouse,Rat

Application

WB, IHC-P, ELISA

Conjugate

Unconjugated

Platform ID

BAB478504674

ABclonal

Headquarters

500W Cummings Park, Ste. 6500 Woburn, MA 01801

ABclonal

Contact

Tel:
Fax:

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameALPK1 Rabbit mAb
Cat. No.A24046
Accession NumberE9QNX4
Gene ID (Entrez)71481
IsotypeIgG
ReactivityMouse,Rat
ConjugationUnconjugated
ApplicationWB, IHC-P, ELISA
Working DilutionsWB:1:1000 - 1:7000 | IHC-P:1:200 - 1:800 | ELISA:Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Clone NumberARC63314
Molecular Weight139kDa
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
PurityAffinity purification
Appearance/FormLiquid
StorageStore at -20℃. Avoid freeze / thaw cycles.; Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Regulatory StatusResearch Use Only

Scientific Background

α- Protein Kinase 1, also known as α- ALPK1 is associated with chronic kidney disease (CKD), myocardial infarction, gout and type 2 diabetes. According to reports, ALPK1 mutations can lead to serious deficits in motor coordination in mice. ALPK1 can enhance the expression of pro-inflammatory cytokines, including IL-1, in cultured human THP1 and human embryonic kidney 293 (HEK293) cells (PMID: 31557402, PMID: 26275947) β、 IL-8 and TGF- β 1. The ALPK1 short subtype (108 kDa) is highly expressed in the brain, spinal cord, heart, lungs, spleen, thymus, small intestine, skin, and testes, while detecting skeletal muscle and kidney. ALPK1 isoform (130 kDa) appears in the heart, lungs, thymus, and skin. As a novel innate immune receptor, ALPK1 can recognize bacteria-derived small molecule ADP-heptose and activate the immune response (PubMed: 30111836, PubMed: 30111836)

Synonyms

Alpha-kinase 1; ALPK1

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.