AP1S1 (F8K5S) Rabbit Monoclonal Antibody#32979,Cell Signaling Technology (CST),32979

The adaptor protein complex 1 (AP-1) is a heterotetrameric protein complex composed of two large adaptins (AP1G1 and AP1B1), a medium adaptin (AP1M1 or AP1M2), and one of several small adaptins (AP3S1, AP1S2, or AP1S3). AP-1 complexes containing AP1M1 are ubiquitously expressed, while complexes containing AP1M2 display a more restricted tissue expression pattern. Research studies have demonstrated that the AP-1 complex is localized to the trans-Golgi network and recycling endosomes where it regulates the bidirectional trafficking of cargo proteins between these subcellular compartments as well as the biogenesis of secretory vesicles (1-3).AP1S1 is one of three possible small adaptin subunits capable of being incorporated into the AP-1 heterotetrameric complex. Mutations inAP1S1contribute to MEDNIK syndrome, which is characterized by a defect in copper metabolism due to aberrant sorting and trafficking of copper pumps ATP7A and ATP7B (4).Wang, Y.J. et al. (2003)Cell114, 299-310.Stamnes, M.A. and Rothman, J.E. (1993)Cell73, 999-1005.Burgess, J. et al. (2011)Mol Biol Cell22, 2094-105.Martinelli, D. and Dionisi-Vici, C. (2014)Ann N Y Acad Sci1314, 55-63.Alternate NamesAdapter-related protein complex 1 sigma-1A subunit; Adaptor protein complex AP-1 sigma-1A subunit; Adaptor protein complex AP-1 subunit sigma-1A; adaptor related protein complex 1 sigma 1 subunit; adaptor related protein complex 1 subunit sigma 1; Adaptor-related protein complex 1 subunit sigma-1A; adaptor-related protein complex 1, sigma 1 subunit; AP-1 complex subunit sigma-1A; AP19; AP1S1; CLAPS1; Clathrin assembly protein complex 1 sigma-1A small chain; Clathrin coat assembly protein AP19; clathrin-associated/assembly/adaptor protein, small 1 (19kD); EKV3; FLJ92436; Golgi adaptor HA1/AP1 adaptin sigma-1A subunit; HA1 19 kDa subunit; MEDNIK; Sigma 1a subunit of AP-1 clathrin; Sigma-adaptin 1A; SIGMA1A; sigma1A subunit of AP-1 clathrin adaptor complex; Sigma1A-adaptin; WUGSC:H_DJ0747G18.2

Adapter-related protein complex 1 sigma-1A subunit; Adaptor protein complex AP-1 sigma-1A subunit; Adaptor protein complex AP-1 subunit sigma-1A; adaptor related protein complex 1 sigma 1 subunit; adaptor related protein complex 1 subunit sigma 1; Adaptor-related protein complex 1 subunit sigma-1A; adaptor-related protein complex 1, sigma 1 subunit; AP-1 complex subunit sigma-1A; AP19; AP1S1; CLAPS1; Clathrin assembly protein complex 1 sigma-1A small chain; Clathrin coat assembly protein AP19; clathrin-associated/assembly/adaptor protein, small 1 (19kD); EKV3; FLJ92436; Golgi adaptor HA1/AP1 adaptin sigma-1A subunit; HA1 19 kDa subunit; MEDNIK; Sigma 1a subunit of AP-1 clathrin; Sigma-adaptin 1A; SIGMA1A; sigma1A subunit of AP-1 clathrin adaptor complex; Sigma1A-adaptin; WUGSC:H_DJ0747G18.2