AP2A2 (E9Q1O) Rabbit Monoclonal Antibody#55521,Cell Signaling Technology (CST),55521

The adaptor-protein 2 (AP-2) coat assembly protein complex is an important component of clathrin-coated pits involved in receptor-mediated endocytosis at the plasma membrane (1-3). Each AP-2 heterotetramer is composed of α, β, μ, and σ protein subunits. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into clathrin-coated vesicles destined for incorporation into the endosomal compartment. AP-2 complex subunit alpha-2 (AP2A2) is one of two large alpha-type adaptins that exist within the AP-2 complex. Research studies have shown that AP2A2 works in concert with AP-2 sigma subunits to facilitate the recognition of [ED]-X-X-X-L-[LI] endocytic motifs embedded within the cytoplasmic tails of membrane cargo proteins destined for the endosomal compartment (4).Kirchhausen, T. (2002)Cell109, 413-6.Ohno, H. et al. (1995)Science269, 1872-5.Traub, L.M. (2003)J Cell Biol163, 203-8.Owen, D.J. et al. (2004)Annu Rev Cell Dev Biol20, 153-91.Alternate Names100 kDa coated vesicle protein C; Adapter-related protein complex 2 alpha-2 subunit; adapter-related protein complex 2 subunit alpha-2; adaptin, alpha B; Adaptor protein complex AP-2 subunit alpha-2; adaptor related protein complex 2 alpha 2 subunit; adaptor related protein complex 2 subunit alpha 2; Adaptor-related protein complex 2 subunit alpha-2; adaptor-related protein complex 2, alpha 2 subunit; ADTAB; Alpha-adaptin C; Alpha2-adaptin; AP-2 complex subunit alpha-2; AP2A2; CLAPA2; Clathrin assembly protein complex 2 alpha-C large chain; clathrin-associated/assembly/adaptor protein, large, alpha 2; HIP-9; HIP9; Huntingtin interacting protein J; Huntingtin yeast partner J; Huntingtin-interacting protein 9; Huntingtin-interacting protein J; HYPJ; KIAA0899; Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit

100 kDa coated vesicle protein C; Adapter-related protein complex 2 alpha-2 subunit; adapter-related protein complex 2 subunit alpha-2; adaptin, alpha B; Adaptor protein complex AP-2 subunit alpha-2; adaptor related protein complex 2 alpha 2 subunit; adaptor related protein complex 2 subunit alpha 2; Adaptor-related protein complex 2 subunit alpha-2; adaptor-related protein complex 2, alpha 2 subunit; ADTAB; Alpha-adaptin C; Alpha2-adaptin; AP-2 complex subunit alpha-2; AP2A2; CLAPA2; Clathrin assembly protein complex 2 alpha-C large chain; clathrin-associated/assembly/adaptor protein, large, alpha 2; HIP-9; HIP9; Huntingtin interacting protein J; Huntingtin yeast partner J; Huntingtin-interacting protein 9; Huntingtin-interacting protein J; HYPJ; KIAA0899; Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit