APC Anti-CD9 antibody [EM-04],Abcam,AB82392

Target data Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (PubMed : 10634790, PubMed : 10634791, PubMed : 10700183, PubMed : 14715942). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (PubMed : 10634790, PubMed : 10634791, PubMed : 10700183, PubMed : 21690351). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (PubMed : 23575678). In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles. Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (PubMed : 12796480). Acts as a receptor for PSG17 (PubMed : 11805154). Involved in platelet activation and aggregation (PubMed : 14715942). Regulates paranodal junction formation (PubMed : 14715942). Involved in cell adhesion, cell motility and tumor metastasis (By similarity). Also regulates integrin-dependent migration of macrophages, particularly relevant for inflammatory response in the lung (PubMed : 18662991). See full target information CD9 antigen