APC/Fire 750 anti-human CD123 Antibody anti-CD123 - 6H6,BioLegend,306042
Clone 6H6 does not inhibit IL-3 binding to low- or high-affinity IL-3Rs. Additional reported applications (for the relevant formats) include: Western blotting1, immunoprecipitation1, and immunohistochemical staining of acetone-fixed frozen sections2and also paraformaldehyde fixed paraffin embedded tissue7.
Host
Mouse
Reactivity
Human
Application
FC -Quality tested
Platform ID
BAB320780418
BioLegend
Contact
Tel: 1-858-455-9588
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Product Specifications
Scientific Background
Specifications
NameAPC/Fire 750 anti-human CD123 Antibody anti-CD123 - 6H6
Cat. No.306042
HostMouse
RRIDAB_2750162 (BioLegend Cat. No. 306041)AB_2750163 (BioLegend Cat. No. 306042)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationFC -Quality tested
ClonalityMonoclonal
Clone Number6H6
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetCD123
ImmunogenHuman IL-3Rα transfected COS cells.
PurityThe antibody was purified by affinity chromatography and conjugated with APC/Fire™ 750 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only
Scientific Background
CD123 is the 70 kD transmembrane α chain of the IL-3 receptor. Alone, CD123 binds IL-3 with low affinity; when CD123 associates with CD131 (common β chain), it binds IL-3 with high affinity. CD123 does not transduce intracellular signals upon binding IL-3 and requires the β chain for this function. CD123 is expressed by myeloid precursors, macrophages, dendritic cells, mast cells, basophils, megakaryocytes, and some B cells.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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