APC Recombinant Antibody, AbBy Fluor-680 Conjugated,Bioss,bsm-61249r-bf680-100ul

Host

Rabbit

Reactivity

Human, Mouse, Rat

Application

WB, IF(IHC-P)

Conjugate

AbBy Fluor-680

Platform ID

BAB488853267

Bioss

Headquarters

300 Tradecenter Dr, ste 4610Woburn, Massachusetts 01801 - U.S.A.

Bioss

Contact

Tel: +1.781.569.5821
Fax: +1.781.731.9286

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameAPC Recombinant Antibody, AbBy Fluor-680 Conjugated
Cat. No.bsm-61249r-bf680-100ul
Accession NumberP25054
Gene ID (Entrez)324
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse, Rat
ConjugationAbBy Fluor-680
ApplicationWB, IF(IHC-P)
Working DilutionsWB:1:500-2000 | IF(IHC-P):IFIHC-P1:50-200
ClonalityRecombinant
ConcentrationLot dependent
PurityPurified by Protein A.
FormulationAqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
StorageStore at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Scientific Background

Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton.

Synonyms

APC; APC protein; Adenomatous polyposis coli protein; DP2.5; mAPC.

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