APC anti-human CD157 (BST-1) Antibody, CD157, W21007F,BioLegend,382109

Host

Rat

Reactivity

Human

Application

FC - Quality tested

Platform ID

BAB023144501

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

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Product Specifications
Scientific Background

Specifications

NameAPC anti-human CD157 (BST-1) Antibody, CD157, W21007F
Cat. No.382109
HostRat
RRIDAB_2941560 (BioLegend Cat. No. 382109)AB_2941560 (BioLegend Cat. No. 382110)
IsotypeRat IgG2a, λ
ReactivityHuman
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberW21007F
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetCD157
ImmunogenhCD157 stable transfectant followed by recombinant protein (aa29-293)
PurityThe antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD157, also known as Bone Marrow Stromal Cell Antigen 1 (BST1), is a GPI-anchored glycoprotein. It is an ectoenzyme that has both cyclic ADP-ribose hydrolase and ADP-ribosyl cyclase activities. It is prevalently expressed by cells of the myelomonocytic lineage, and modulates adhesion of neutrophils and monocytes to the extracellular matrix. CD157 is expressed in 97% of primary acute myeloid leukemia samples, and is used as a marker for diagnosis of Paroxysmal Nocturnal Hemoglobinuria, a disease caused by intrinsic deficiency of GPI anchors.

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