APC anti-human CD158i (KIR2DS4) Antibody, CD158i, S22012A,BioLegend,335105

CD158 molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins that are expressed on specific subsets of NK and T cells. KIRs are characterized as having either two (KIR2D) or three (KIR3D) Ig-like extracellular domains. Some KIRs with long cytoplasmic domains contain ITIMs and possess inhibitory functions, while others with short cytoplasmic region lack ITIMs and have activating functions. Fifteen polymorphic KIR genes have been identified in humans, contributing to the extensive diversity of KIR phenotypes observed in individuals.CD158i is an activating receptor with two Ig-like domains and a short cytoplasmic region. KIR2DS4 is reported to bind to certain HLA-C molecules and HLA-A*11.