APC anti-human CD200 (OX2) Antibody, CD200, A18042B,BioLegend,399808

CD200, also known as OX2, is a member of the immunoglobulin superfamily (IgSF). It is a monomorphic cell surface glycoprotein expressed on thymocytes, neurons, endothelium, follicular dendritic cells within lymphoid organs, and a subset of CD34⁺ progenitor cells. CD200 is also expressed at low levels on certain smooth muscle cells and B lymphocytes, but is not detected on NK cells, monocytes, granulocytes, or platelets. CD200 co-stimulates T cell proliferation and is implicated in the regulation of myeloid cell activity in a variety tissues. The interaction between CD200 (OX2) and its receptor, CD200R (OX2R), plays an important role in modulating macrophage and granulocyte activation, which may contribute to pathways that suppress and limit macrophage-induced inflammatory damage in tissues.