APC anti-human CD277 (BTN3A1) Recombinant Antibody, CD277, 34-7.Rec,BioLegend,383204

This product was formerly named “anti-human CD277 (BTN3A1).” The 34-7.Rec clone has been confirmed to recognize BTN3A3. Cross-reactivity with other BTN3A subfamily members has not been tested.

Host

Mouse

Reactivity

Human

Application

FC - Quality tested

Platform ID

BAB180925052

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

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Product Specifications
Scientific Background

Specifications

NameAPC anti-human CD277 (BTN3A1) Recombinant Antibody, CD277, 34-7.Rec
Cat. No.383204
HostMouse
RRIDAB_3097456 (BioLegend Cat. No. 383203)AB_3097456 (BioLegend Cat. No. 383204)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationFC - Quality tested
ClonalityRecombinant
Clone Number34-7.Rec
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetCD277
ImmunogenpRC-CMV-BTN3A3
PurityThe antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

Butyrophilin subfamily 3A (BTN3A), also known as CD277, is a 56 kD type 1 transmembrane glycoprotein. The butyrophilin (BT)/B7 3A family includes three members, BTN3A1, BTN3A2, and BTN3A3, which share a highly conserved extracellular IgV-like domain. BTN3A is broadly expressed in various immune cells including T cells, B cells, NK cells, monocytes, dendritic cells, endothelial cells, and some tumor cells. It plays a role in T cell activation, regulating their proliferation and release of IFNƳ and other cytokines.Clone 34-7.Rec has been shown to bind to a V region of BTN3A3 that is shared with BTN3A1 and BTN3A2.

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