APC anti-human CD54 Antibody anti-CD54 - HCD54,BioLegend,322712

Additional reported applications (for the relevant formats) include:in vitroblocking of lymphoctes interaction1. The Ultra-LEAF™ purified antibody (Endotoxin <0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 322721 & 322722).

Host

Mouse

Reactivity

Human

Application

FC - Quality tested

Platform ID

BAB479626664

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Product Specifications
Scientific Background

Specifications

NameAPC anti-human CD54 Antibody anti-CD54 - HCD54
Cat. No.322712
HostMouse
RRIDAB_535984 (BioLegend Cat. No. 322712)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberHCD54
ConcentrationLot-specific (to obtain lot-specific concentration, please enter the lot number in ourConcentration and Expiration LookuporCertificate of Analysisonline tools.)
TargetCD54
PurityThe antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD54 is a 85-110 kD type I transmembrane protein also known as ICAM-1. It is expressed on activated endothelial cells, high endothelial venules, T and B cells, monocytes/macrophages, granulocytes, and dendritic cells. The expression of ICAM-1 on the cell surface is potently upregulated by activation; a soluble form of ICAM-1 can be released from the cell surface. CD54 plays a role in cellular adhesion and is involved in inflammation and leukocyte extravasation. CD54 has also been shown to be the major cellular receptor for rhinovirus. ICAM-1 binds to CD11a/CD18 (LFA-1), CD11b/CD18 (Mac-1), CD11c/CD18 (p150, 95) as well as hyaluronan and fibrinogen.

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