APC anti-human Glypican-4 Antibody, Glypican-4, A21050B,BioLegend,386407

Glypican-4 is a cell surface heparan sulfate proteoglycan that contains a core protein anchored to the cytoplasmic membrane via a GPI anchor. Glypicans function as coreceptors for a variety of growth factors including Wnt, bone morphogenetic proteins (BMPs), fibroblast growth factors, and Hedgehog. In particular, Glypican-4 enhances the Wnt3a dependent β-catenin pathway and the Wnt5a-dependent non-canonical Wnt signaling. Glypican-4 plays a role in the control of cell division and growth regulation and is upregulated in pancreatic cancer and colorectal cancer where it is involved in promoting chemoresistance. Glypican-4 also regulates glutamatergic synapse formation and function in the developing brain.