APC anti-human IL-31 Antibody anti-IL-31 - 1D10B31,BioLegend,659605

Host

Mouse

Reactivity

Human

Application

ICFC - Quality tested

Platform ID

BAB731439529

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

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Product Specifications
Scientific Background

Specifications

NameAPC anti-human IL-31 Antibody anti-IL-31 - 1D10B31
Cat. No.659605
HostMouse
RRIDAB_2566762 (BioLegend Cat. No. 659605)AB_2566763 (BioLegend Cat. No. 659606)
IsotypeMouse IgG2b, κ
ReactivityHuman
ApplicationICFC - Quality tested
ClonalityMonoclonal
Clone Number1D10B31
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetIL-31
ImmunogenFull length human IL-31 recombinant protein expressed inE. coli.
PurityThe antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

IL-31, produced mainly by activated CD4+T cells, is a newly discovered helical cytokine belonging to the gp130/IL6 cytokine family. IL-31 is closely related in structure to IL-6, IL-11, and IL-27. Binding of IL-31 to its receptor activates JAK/STAT, PI3K/AKT, and MAPK pathways. IL-31 acts on a broad range of immune and non-immune cells and thus possesses potential pleiotropic physiological functions, such as regulating hematopoiesis and immune response. Human IL-31 is also involved in inflammatory bowel disease, airway hypersensitivity, and dermatitis.

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