APC anti-human/mouse CD266 (Fn14, TWEAK R) Antibody, CD266, ITEM-4,BioLegend,314107
Additional reported applications (for the relevant formats) include: Western blotting3,4, immunofluorescence3,4, and immunohistochemistry of frozen sections5and formalin-fixed paraffin-embedded sections3. ITEM-4 antibody has no effect on TWEAK-induced MAPK activation in RAW cells1.
Host
Mouse
Reactivity
Human, Mouse
Application
FC -Quality tested
Platform ID
BAB677365497
BioLegend
Contact
Tel: 1-858-455-9588
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Product Specifications
Scientific Background
Specifications
NameAPC anti-human/mouse CD266 (Fn14, TWEAK R) Antibody, CD266, ITEM-4
Cat. No.314107
HostMouse
RRIDAB_2800830 (BioLegend Cat. No. 314107)AB_2810477 (BioLegend Cat. No. 314108)
IsotypeMouse IgG2b, κ
ReactivityHuman, Mouse
ApplicationFC -Quality tested
ClonalityMonoclonal
Clone NumberITEM-4
Concentration0.2 mg/ml
TargetCD266
ImmunogenHuman Fn14 transfected P815
PurityThe antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only
Scientific Background
CD266 is a 14 kD transmembrane protein known as TWEAK receptor (TWEAK-R) or fibroblast growth factor inducible 14 (Fn14). It is member 12A of the tumor necrosis factor receptor superfamily (TNFRSF12A) expressed at low levels in a variety of tissues, such as heart, placenta, lung, muscle, and pancreas. TWEAK-R binds TWEAK (CD255) and interacts with the cytoplasmic proteins TRAF1, 2, and 3. The engagement of Fn14 can induce cell death and may play a role in inflammation, hepatocyte growth, and liver neoplasia.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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