APC anti-mouse CD117 (c-kit) Antibody, CD117, S18020A,BioLegend,161505

S18020A has been tested to block the ligand binding of SCF on c-Kit which is determined by the phosphorylation of ERK1/2 in c-Kit signaling.

Host

Rat

Reactivity

Mouse

Application

FC - Quality tested

Platform ID

BAB821007780

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

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Product Specifications
Scientific Background

Specifications

NameAPC anti-mouse CD117 (c-kit) Antibody, CD117, S18020A
Cat. No.161505
HostRat
RRIDAB_2922496 (BioLegend Cat. No. 161505)AB_2922496 (BioLegend Cat. No. 161506)
IsotypeRat IgG1, κ
ReactivityMouse
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberS18020A
Concentration0.2 mg/mL
TargetCD117
ImmunogenMouse c-kit transfectants
PurityThe antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD117 is a 145 kD immunoglobulin superfamily member also known as c-kit and stem cell factor receptor (SCFR). It is a transmembrane tyrosine-kinase receptor that binds the c-kit ligand (also known as steel factor, stem cell factor, and mast cell growth factor). CD117 is expressed on hematopoietic stem cells (including multipotent hematopoietic stem cells, progenitors committed to myeloid and/or erythroid lineages, and T and B cell precursors), mast cells, and acute myeloid leukemia (AML) cells. CD117 interaction with its ligand is critical for the development of hematopoietic stem cells.

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