APC anti-mouse CD172a (SIRPα) Recombinant Antibody , CD172a, QA20A06,BioLegend,108606
Clone QA20A06 can completely block the binding of clone P84 on target cells.
Host
Mouse
Reactivity
Mouse
Application
FC - Quality tested
Platform ID
BAB894894826
BioLegend
Contact
Tel: 1-858-455-9588
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Product Specifications
Scientific Background
Specifications
NameAPC anti-mouse CD172a (SIRPα) Recombinant Antibody , CD172a, QA20A06
Cat. No.108606
HostMouse
RRIDAB_3097475 (BioLegend Cat. No. 108605)AB_3097475 (BioLegend Cat. No. 108606)
IsotypeMouse IgG1, κ
ReactivityMouse
ApplicationFC - Quality tested
ClonalityRecombinant
Clone NumberQA20A06
Concentration0.2 mg/mL
TargetCD172alpha
PurityThe antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only
Scientific Background
CD172a, also known as SIRPα, is a type I transmembrane protein with one V-set Ig-like and two C-set Ig-like domains in the extracellular portion, and two ITIM motifs and a proline-rich region in the cytoplasmic tail. CD172a is expressed by monocytes, macrophages, myeloid cells, and neuronal tissue. The phosphorylation of SIRPα ITIMs induces the recruitment and activation of the tyrosine phosphatases PTPN6 and PTPN11, resulting in the negative regulation of several biological processes. The ligands of CD172a are CD47, SP-A, and SP-D.
Category Paths
- Products>Primary Antibodies>Recombinant Antibodies
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