APC anti-mouse CD339 Jagged 1 Antibody anti-CD339 - HMJ1-29,BioLegend,130914

Additional reported applications (for the relevant formats) include:in vivoblocking of Jagged 1 in EAE1and immunohistochemical staining of frozen spleen sections2.

Host

Armenian Hamster

Reactivity

Mouse

Application

FC - Quality tested

Platform ID

BAB173617297

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Product Specifications
Scientific Background

Specifications

NameAPC anti-mouse CD339 Jagged 1 Antibody anti-CD339 - HMJ1-29
Cat. No.130914
HostArmenian Hamster
RRIDAB_2561304 (BioLegend Cat. No. 130913)AB_2561305 (BioLegend Cat. No. 130914)
IsotypeArmenian Hamster IgG
ReactivityMouse
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberHMJ1-29
Concentration0.2 mg/ml
TargetCD339
ImmunogenMurine Jagged 1-Fc fusion protein
PurityThe antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD339, also known as Jagged 1, is a 135 kD type 1 transmembrane protein, with one DSL (Delta, Serrate, LagZ) domain, fifteen EGF-like domains, and one cysteine-rich region. Jagged 1 is expressed by many cell types including macrophages, subsets of dendritic cells, astrocytes, stromal, and epithelial cells. CD339 regulates cell fate decisions in various tissues, and has an important role in neurogenesis and development of the cardiovascular system. Studies suggest Jagged 1 is involved in Th2 polarization and Treg induction.

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