APC anti-mouse Integrin αVβ6 Antibody, Integrin αVβ6, S20012B,BioLegend,117511

Clone S20012B does not affect the binding of clone S20012E on target cells.Clone S20012B does not react with mouse integrin αVβ8.

Host

Rat

Reactivity

Mouse

Application

FC - Quality tested

Platform ID

BAB260175729

BioLegend

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Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NameAPC anti-mouse Integrin αVβ6 Antibody, Integrin αVβ6, S20012B
Cat. No.117511
HostRat
RRIDAB_3683147 (BioLegend Cat. No. 117511)AB_3683147 (BioLegend Cat. No. 117512)
IsotypeRat IgG1, κ
ReactivityMouse
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberS20012B
Concentration0.2 mg/mL
TargetIntegrin alphaVbeta6
ImmunogenMouse αvβ6 integrin-transfected cells
PurityThe antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

Integrins are heterodimeric transmembrane receptors that mediate cell-cell and cell-extracellular matrix adhesion. Integrin β6 associates exclusively with the αV subunit forming an αVβ6 complex that is expressed specifically on epithelial cells. Integrin αVβ6 is a receptor for multiple extracellular matrix (ECM) proteins, including tenascin, fibronectin, and vitronectin. It is also a receptor for the latency-associated peptide (LAP) of TGF-β and is involved in TGF-β activation. Its expression is upregulated during wound healing and in some cancers.

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