APC anti-mouse LPAM-1 Integrin alpha4beta7 Antibody anti-LPAM-1 - DATK32,BioLegend,120608

Additional reported applications (for the relevant formats) include:in vitroandin vivoblocking of cell adhesion1-4,in vitroinduction of TK1 cell aggregation1, immunoprecipitation4, and immunohistochemical staining of frozen sections5. It has been reported that the DATK32 mAb is able to block a4ß7 mediated lymphocyte adhesion to VCAM-1, MAdCAM-1, and fibronectinin vitroandin vivo.

Host

Rat

Reactivity

Mouse

Application

FC - Quality tested

Platform ID

BAB967882304

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

Email:

Product Specifications
Scientific Background

Specifications

NameAPC anti-mouse LPAM-1 Integrin alpha4beta7 Antibody anti-LPAM-1 - DATK32
Cat. No.120608
HostRat
RRIDAB_10719833 (BioLegend Cat. No. 120607)AB_10730607 (BioLegend Cat. No. 120608)
IsotypeRat IgG2a, κ
ReactivityMouse
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberDATK32
Concentration0.2 mg/ml
TargetLPAM-1
ImmunogenTK1 cells
PurityThe antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

DATK32 antibody is specific for a combinatorial determinate of integrin α4β7complex. Integrin α4β7 is composed of a 150 kD (α4 or CD49d) and a 130 kD (β7) heterodimer, also known as CD49d/β7 or LPAM-1. Belonging to the Ig superfamily, it is found on the majority of peripheral lymphocytes and subsets of thymocytes and bone marrow cells (including mast cell progenitors). Integrin α4β7 binds its ligands, VCAM-1 (CD106), MAdCAM-1 and fibronectin, and plays an important role in lymphocytes adhesion and the direction of migration of blood lymphocytes to the intestine and associated lymphoid tissues.

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.