APOBEC3A (UMN-13) Rabbit Monoclonal Antibody#72514,Cell Signaling Technology (CST),72514

APOBEC3A (UMN-13) Rabbit Monoclonal Antibody recognizes endogenous levels of total APOBEC3A protein. This antibody does not cross-react with APOBEC3B or APOBEC3G proteins. This antibody detects a 40 kDa protein of unknown identity in some tissues.

Host

Rabbit

Reactivity

Human

Application

Western Blotting: 1:1000 Immunohistochemistry (Paraffin): 1:800 - 1:3200

Platform ID

BAB901058073

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameAPOBEC3A (UMN-13) Rabbit Monoclonal Antibody#72514
Cat. No.72514
Accession NumberP31941, 200315
Gene ID (Entrez)31941, 200315
HostRabbit
SensitivityEndogenous
ReactivityHuman
ApplicationWestern Blotting: 1:1000 Immunohistochemistry (Paraffin): 1:800 - 1:3200
Molecular Weight23
ImmunogenIgG
FormulationSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C.Do not aliquot the antibody.For a carrier free (BSA and azide free) version of this product see product #51519.
StorageSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C.Do not aliquot the antibody.For a carrier free (BSA and azide free) version of this product see product #51519.
Regulatory StatusResearch Use Only

Scientific Background

Members of the APOBEC3 subfamily of cytosine deaminases (APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H) function in innate immunity by preventing viral DNA replication, including that of HIV-1 (1-2). APOBEC3A expression is upregulated in several human cancers, and is a major source of mutation in breast cancer (3). APOBEC3A contributes to chromosomal instability and disease progression in pancreatic cancer (4), and upregulates PD-L1 expression in cancer cells (5).Olson, M.E. et al. (2018)Cell Chem Biol25, 36-49.Siriwardena, S.U. et al. (2016)Chem Rev116, 12688-12710.Cortez, L.M. et al. (2019)PLoS Genet15, e1008545.Wörmann, S.M. et al. (2021)Nat Cancer2, 1338-1356.Zhao, K. et al. (2021)Mol Cancer Res19, 1571-1582.Alternate NamesA3A; ABC3A; APOBEC3A; apolipoprotein B mRNA editing enzyme catalytic subunit 3A; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A; ARP3; bK150C2.1; DNA dC->dU-editing enzyme APOBEC-3A; phorbolin 1; Phorbolin-1; PHRBN; Probable DNA dC->dU-editing enzyme APOBEC-3A

Synonyms

A3A; ABC3A; APOBEC3A; apolipoprotein B mRNA editing enzyme catalytic subunit 3A; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A; ARP3; bK150C2.1; DNA dC->dU-editing enzyme APOBEC-3A; phorbolin 1; Phorbolin-1; PHRBN; Probable DNA dC->dU-editing enzyme APOBEC-3A

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