ARID1A/BAF250A (D2A8U) Rabbit Monoclonal Antibody#12354,Cell Signaling Technology (CST),12354

ATP-dependent chromatin remodeling complexes play an essential role in the regulation of nuclear processes such as transcription and DNA replication and repair (1,2). The SWI/SNF chromatin remodeling complex consists of more than 10 subunits and contains a single molecule of either BRM or BRG1 as the ATPase catalytic subunit. The activity of the ATPase subunit disrupts histone-DNA contacts and changes the accessibility of crucial regulatory elements to the chromatin. The additional core and accessory subunits play a scaffolding role to maintain stability and provide surfaces for interaction with various transcription factors and chromatin (2-5). The interactions between SWI/SNF subunits and transcription factors, such as nuclear receptors, p53, Rb, BRCA1, and MyoD, facilitate recruitment of the complex to target genes for regulation of gene activation, cell growth, cell cycle, and differentiation processes (1,6-9).ARID1A is one of the accessory subunits of the SWI/SNF complex that is an essential part of the esBAF (mouse embryonic stem cell specific SWI/SNF complex). ARID1A is critical for ES cell pluripotency and differentiation into mesoderm-derived cardiomyocytes and adipocytes (10). In addition, ARID1A has been found to be frequently mutated in several cancers such as uterine and ovarian endometrioid carcinoma and ovarian clear cell carcinoma (11-13).Ho, L. and Crabtree, G.R. (2010)Nature463, 474-84.Becker, P.B. and Hörz, W. (2002)Annu Rev Biochem71, 247-73.Eberharter, A. and Becker, P.B. (2004)J Cell Sci117, 3707-11.Bowman, G.D. (2010)Curr Opin Struct Biol20, 73-81.Gangaraju, V.K. and Bartholomew, B. (2007)Mutat Res618, 3-17.Lessard, J.A. and Crabtree, G.R. (2010)Annu Rev Cell Dev Biol26, 503-32.Morettini, S. et al. (2008)Front Biosci13, 5522-32.Wolf, I.M. et al. (2008)J Cell Biochem104, 1580-6.Simone, C. (2006)J Cell Physiol207, 309-14.Guan, B. et al. (2011)Am J Surg Pathol35, 625-32.Gao, X. et al. (2008)Proc Natl Acad Sci U S A105, 6656-61.Jones, S. et al. (2010)Science330, 228-31.Wiegand, K.C. et al. (2010)N Engl J Med363, 1532-43.Alternate NamesARI1A; ARID domain-containing protein 1A; ARID1A; AT rich interactive domain 1A (SWI- like); AT rich interactive domain 1A (SWI-like); AT-rich interaction domain 1A; AT-rich interactive domain-containing protein 1A; B120; BAF250; BAF250A; BM029; brain protein 120; BRG1-associated factor 250; BRG1-associated factor 250a; C1orf4; chromatin remodeling factor p250; CSS2; ELD; hELD; hOSA1; MRD14; Osa homolog 1; OSA1; OSA1 nuclear protein; P270; SMARCF1; SWI-like protein; SWI/SNF complex protein p270; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily f, member 1; SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1

ARI1A; ARID domain-containing protein 1A; ARID1A; AT rich interactive domain 1A (SWI- like); AT rich interactive domain 1A (SWI-like); AT-rich interaction domain 1A; AT-rich interactive domain-containing protein 1A; B120; BAF250; BAF250A; BM029; brain protein 120; BRG1-associated factor 250; BRG1-associated factor 250a; C1orf4; chromatin remodeling factor p250; CSS2; ELD; hELD; hOSA1; MRD14; Osa homolog 1; OSA1; OSA1 nuclear protein; P270; SMARCF1; SWI-like protein; SWI/SNF complex protein p270; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily f, member 1; SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1