ASH2L Antibody (YA1723),MedChemexpress,HY-P81978

ASH2L Antibody (YA1723) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ASH2L.

Host

Rabbit

Reactivity

Human,Rat

Application

WB,ICC/IF,IP

Conjugate

Non-conjugated

Platform ID

BAB135850837

Suppliers

(1)

Biomedical Life sciences

91-9676853503

[email protected]
Country:India
City:Madīnat Ḩamad
Plot No.A-2811121/A&B/3.IP NACHARAM. ALA NACHARAM, Road N0-15, Hyderabad Medchal Malkajgiri, Telangana-500076
Master of Bioactive Molecules

MedChemexpress

Master of Bioactive Molecules

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Contact

Tel: 609-228-6898
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Email:

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Product Specifications
Scientific Background
Synonyms

Specifications

NameASH2L Antibody (YA1723)
Cat. No.HY-P81978
Accession NumberQ9UBL3
Gene ID (Entrez)9070
HostRabbit
IsotypeIgG
SensitivityEndogenous
ReactivityHuman,Rat
ConjugationNon-conjugated
ApplicationWB,ICC/IF,IP
Working DilutionsWB: 1:500-1:1000; ICC/IF: 1:50-1:200; IP: 1:20
ClonalityRecombinant,Monoclonal
Clone NumberYA1723
Molecular WeightPredicted band size: 69 kDa; Observed band size: 80 kDa
ImmunogenA synthetic peptide of human ASH2L
PurityAffinity Purified
Appearance/FormLiquid
ShippingShipping with blue ice.
FormulationSupplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
StorageStored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

ASH2L is a transcriptional regulator that functions as a component or associated component of certain histone methyltransferase complexes, regulating transcription by recruiting these complexes to gene promoters. It is part of the Set1/Ash2 histone methyltransferase (HMT) complex, which specifically methylates histone H3 at 'Lys-4', but not if the neighboring 'Lys-9' residue is already methylated. As a component of the MLL1/MLL complex, it participates in the methylation and dimethylation of histone H3 at 'Lys-4'. ASH2L may play a role in hematopoiesis. In association with RBBP5 and WDR5, it stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A, and SETD1B.

Synonyms

ASH2; Bre2; ASH2L1; ASH2L2

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