Acetyl Coenzyme A Carboxylase Antibody (YA6016),MedChemexpress,HY-P86324

ACC-beta (acetyl-CoA carboxylase beta) is a mitochondrial enzyme that plays a central role in fatty acid metabolism by catalyzing the carboxylation of acetyl-CoA to malonyl-CoA. The reaction occurs in two steps: ATP-dependent carboxylation of biotin on the biotin carboxyl carrier (BCC) domain, followed by transfer of the carboxyl group to acetyl-CoA (PubMed:19236960, PubMed:20457939, PubMed:20952656, PubMed:26976583). The product malonyl-CoA allosterically inhibits carnitine palmitoyltransferase 1, thereby negatively regulating fatty acid oxidation (by similarity). Together with its cytosolic isozyme ACACA, which is involved in de novo fatty acid biosynthesis, it promotes lipid storage (by similarity).

ACACB,Acetyl CoA carboxylase 2,ACC beta,ACC2,ACCB,AcetylCoA carboxylase 2,ACCbeta,ACCβ,ACC β,