Alexa Fluor® 405 Anti-PDHB antibody [EPR11097(B)],Abcam,AB210029

Host

Rabbit

Reactivity

Human, Human, Mouse, Rat

Application

ICC/IF, Flow Cyt, Flow Cyt (Intra), IHC-P

Conjugate

Alexa Fluor® 405

Platform ID

BAB962928361

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAlexa Fluor® 405 Anti-PDHB antibody [EPR11097(B)]
Cat. No.AB210029
HostRabbit
IsotypeIgG
ReactivityHuman, Human, Mouse, Rat
ConjugationAlexa Fluor® 405
ApplicationICC/IF, Flow Cyt, Flow Cyt (Intra), IHC-P
ClonalityMonoclonal
Clone NumberEPR11097(B)
Concentration0.5 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Together with PDHA1 forms the heterotetrameric E1 subunit of the pyruvate dehydrogenase (PDH) complex (PubMed : 17474719, PubMed : 19081061). The PDH complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle (Probable). It contains multiple copies of three enzymatic components : pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3) (Probable). The E1 subunit catalyzes both the thiamine pyrophosphate (TPP)-dependent decarboxylation of pyruvate and the reductive acetylation of a lipoyl group covalently linked to the lipoyl-bearing domains of E2 (PubMed : 19081061). See full target information PDHB

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