Alexa Fluor® 488 Anti-CPT1A antibody [8F6AE9],Abcam,AB171449
What is this antibody validated in? Alexa Fluor® 488 Anti-CPT1A antibody [8F6AE9] (ab171449) is a mouse monoclonal antibody and is validated for use in Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunocytochemistry/immunofluorescence (ICC/IF) in Human samples. Trusted by the scientific community Anti-CPT1A [8F6AE9] Alexa Fluor® 488 (ab171449) was first used in a scientific publication in 2013 and has been cited over 10 times in peer-reviewed journals. Related products Antibody clone 8F6AE9 is also available pre-conjugated to a variety of labels for your convenience – Anti-CPT1A Alexa Fluor® 488 [8F6AE9] (ab171449). Specificity confirmed The specificity of Alexa Fluor® 488 Anti-CPT1A antibody [8F6AE9] (ab171449) has been confirmed by Flow Cytometry testing in CPT1A Knockout HAP1 cells. Other related products We have a range of other formats of antibody clone [8F6AE9] also available for your convenience: ab128568 , Alexa Fluor® 488 - ab171449, HRP - ab198494 , Carrier free - ab300265 Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or [email protected].
Host
Mouse
Reactivity
Human
Application
Flow Cyt (Intra), ICC/IF
Conjugate
Alexa Fluor® 488
Platform ID
BAB591239271
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed : 11350182, PubMed : 14517221, PubMed : 16651524, PubMed : 9691089). Also possesses a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity (PubMed : 29425493). Plays an important role in hepatic triglyceride metabolism (By similarity). Also plays a role in inducible regulatory T-cell (iTreg) differentiation once activated by butyryl-CoA that antagonizes malonyl-CoA-mediated CPT1A repression (By similarity). Sustains the IFN-I response by recruiting ZDHCC4 to palmitoylate MAVS at the mitochondria leading to MAVS stabilization and activation (PubMed : 38016475). Promotes ROS-induced oxidative stress in liver injury via modulation of NFE2L2 and NLRP3-mediated signaling pathways (By similarity). See full target information CPT1A
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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