Alexa Fluor® 488 Anti-TMEM119 antibody [106-6] - Microglial marker,Abcam,AB225497

What is this antibody validated in? Alexa Fluor® 488 Anti-TMEM119 antibody [106-6] (ab225497) is a rabbit recombinant monoclonal antibody and is validated for use in Flow Cytometry (Intra), Flow Cytometry (Flow Cyt) in Human, Mouse samples. Related products Antibody clone 106-6 is also available pre-conjugated to a variety of labels for your convenience – Anti-TMEM119 Alexa Fluor® 488 [106-6] (ab225497). Specificity confirmed The specificity of Alexa Fluor® 488 Anti-TMEM119 antibody [106-6] (ab225497) has been confirmed by Flow Cytometry (Intracellular) testing in Tmem119 Knockout Mouse CD11b+ cells samples. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rabbit

Reactivity

Mouse, Human, Human, Mouse

Application

Flow Cyt (Intra), ICC/IF, Flow Cyt

Conjugate

Alexa Fluor® 488

Platform ID

BAB724197949

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAlexa Fluor® 488 Anti-TMEM119 antibody [106-6] - Microglial marker
Cat. No.AB225497
HostRabbit
IsotypeIgG
ReactivityMouse, Human, Human, Mouse
ConjugationAlexa Fluor® 488
ApplicationFlow Cyt (Intra), ICC/IF, Flow Cyt
ClonalityMonoclonal
Clone Number106-6
Concentration0.5 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.02% Sodium azide Constituents: 30% Glycerol (glycerin, glycerine), 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Plays an important role in bone formation and normal bone mineralization (PubMed : 20025746, PubMed : 22416756, PubMed : 26207632). Promotes the differentiation of myoblasts into osteoblasts (PubMed : 20025746, PubMed : 22416756, PubMed : 22579779). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway (PubMed : 21239498, PubMed : 22579779). Up-regulates the expression of ATF4 which plays a central role in osteoblast differentiation (PubMed : 24362451). Essential for normal spermatogenesis and late testicular differentiation (PubMed : 26207632). See full target information Tmem119

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