Alexa Fluor® 488 Anti-beta III Tubulin antibody [2G10] - Neuronal Marker,Abcam,AB195879

What is this antibody validated in? Alexa Fluor® 488 Anti-beta III Tubulin antibody [2G10] (ab195879) is a mouse monoclonal antibody and is validated for use in Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Rat samples. Related products Antibody clone 2G10 is also available pre-conjugated to a variety of labels for your convenience – Anti-beta III Tubulin Alexa Fluor® 488 [2G10] (ab195879). Specificity confirmed The specificity of Alexa Fluor® 488 Anti-beta III Tubulin antibody [2G10] (ab195879) has been confirmed by Immunocytochemistry testing in Tubb3 Knockout HAP1 cells. Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or [email protected].

Host

Mouse

Reactivity

Human, Rat

Application

Flow Cyt (Intra), ICC/IF

Conjugate

Alexa Fluor® 488

Platform ID

BAB713902893

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAlexa Fluor® 488 Anti-beta III Tubulin antibody [2G10] - Neuronal Marker
Cat. No.AB195879
HostMouse
IsotypeIgG2a
ReactivityHuman, Rat
ConjugationAlexa Fluor® 488
ApplicationFlow Cyt (Intra), ICC/IF
ClonalityMonoclonal
Clone Number2G10
Concentration0.5 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (By similarity). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (By similarity). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (By similarity). TUBB3 plays a critical role in proper axon guidance and maintenance (By similarity). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (By similarity). Plays a role in dorsal root ganglion axon projection towards the spinal cord (By similarity). See full target information Tubb3

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