Alexa Fluor® 488 anti-CD68 Antibody, CD68, KP1,BioLegend,916107

For use in immunocytochemistry (ICC), it is recommended to fix/permeabilize with either of the following:- Fixation buffer (Cat. No. 420801) with 100% ice-cold methanol- 100% ice-cold methanol onlyFixation/permeabilization with Fixation buffer (Cat. No. 420801) followed by 0.5 % Triton X-100 is not recommended due to non-specific staining.

Host

Mouse

Reactivity

Human

Application

IHC-P - Quality testedICC - Verified

Platform ID

BAB930089189

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

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Product Specifications
Scientific Background

Specifications

NameAlexa Fluor® 488 anti-CD68 Antibody, CD68, KP1
Cat. No.916107
HostMouse
RRIDAB_3699100 (BioLegend Cat. No. 916107)AB_3699100 (BioLegend Cat. No. 916108)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationIHC-P - Quality testedICC - Verified
ClonalityMonoclonal
Clone NumberKP1
Concentration0.5 mg/mL
TargetCD68
ImmunogenThis antibody was generated using a Lysosomal fraction of human alveolar macrophages.
PurityThe antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

Mouse CD68, also known as macrosialin, is an 85-115 kD member of the lysosomal-associated membrane protein (LAMP) family. It is a heavily glycosylated and predominantly intracellular protein, mainly in late endosomes. Macrosialin is the murine homolog to the human macrophage glycoprotein CD68. It is expressed on tissue macrophages, Langerhans cells and at low levels on dendritic cells. High levels of CD68 expression are detected in activated microglia. LAMP proteins may have functions related to cell-cell interaction or cell-ligand interaction. The biological function of CD68 is not completely understood.

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