Alexa Fluor 488 anti-Tubulin beta 3 TUBB3 Antibody anti-Tubulin beta 3 - TUJ1,BioLegend,801203

Additional reported applications (for the relevant formats) include: flow cytometry4, immunofluorescence microscopy1-5,7, immunohistochemistry5,7, Western blotting8, and spatial biology (IBEX)9,10.This antibody is well characterized and highly reactive to neuron specific Class III ß-tubulin (ßIII). TUJ1 does not identify ß-tubulin found in glial cells. TUJ1 recognizes an epitope located within the last 15 C-terminal residues8.

Host

Mouse

Reactivity

Human, Mouse, Rat

Application

ICC -Quality testedIHC-P, ICFC, 3D IHC -VerifiedSB -Reported in the literature, not verified in house

Platform ID

BAB784425348

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Product Specifications
Scientific Background

Specifications

NameAlexa Fluor 488 anti-Tubulin beta 3 TUBB3 Antibody anti-Tubulin beta 3 - TUJ1
Cat. No.801203
HostMouse
RRIDAB_2564757 (BioLegend Cat. No. 801203)
IsotypeMouse IgG2a, κ
ReactivityHuman, Mouse, Rat
ApplicationICC -Quality testedIHC-P, ICFC, 3D IHC -VerifiedSB -Reported in the literature, not verified in house
ClonalityMonoclonal
Clone NumberTUJ1
Concentration1.0 mg/ml
TargetTubulin beta-3
ImmunogenThis antibody was raised against microtubules derived from rat brain.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.Previous lots (B432255 and prior) of this product may have been formulated in PBS + 50% glycerol + 0.03% thimerosal. For further information please contact BioLegendTechnical SupportorCustomer Service.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

Tubulin is the main component of microtubules. In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation. Mutations in this gene cause congenital fibrosis of the type 3 extraocular muscles. Tubulin beta 3 (TUBB3) is also found in a wide range of tumors. Studies indicate that it is a predictive and prognostic marker in various tumors.

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