Alexa Fluor 488 anti-ZAP-70 Antibody anti-ZAP-70 - A16043B,BioLegend,693506

CD3, CD19, and CD56 co-staining indicates that this clone does not bind B-cells and will not bind Syk. Clone A16043B cross-reacts with mouse species.This clone, A16043B, recognizes both non-phosphorylated ZAP-70 and phosphorylated forms of ZAP-70.

Host

Mouse

Reactivity

Human, Mouse

Application

ICFC -Quality tested

Platform ID

BAB048143760

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Product Specifications
Scientific Background

Specifications

NameAlexa Fluor 488 anti-ZAP-70 Antibody anti-ZAP-70 - A16043B
Cat. No.693506
HostMouse
RRIDAB_2715832 (BioLegend Cat. No. 693505)AB_2715833 (BioLegend Cat. No. 693506)
IsotypeMouse IgG1, κ
ReactivityHuman, Mouse
ApplicationICFC -Quality tested
ClonalityMonoclonal
Clone NumberA16043B
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetZAP-70
ImmunogenHuman ZAP 70 peptide phosphorylated at Y493. Complete Freund’s adjuvant.
PurityThe antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

ZAP-70 is a 70kD protein expressed near the surface membrane of T-cells and NK cells. It is part of the intracellular signaling mechanism of the T-cell receptor, and plays integral role in T-cell signaling where it interacts with CD3-ζ to phosphorylate transmembrane protein LAT, which facilitates the binding of many signaling proteins. ZAP-70 plays a key role in the activation of T-cells, and their subsequent proliferation, differentiation, and production of cytokines in response to varied stimuli. It is used clinically as a prognostic marker helping differentiate the various types of chronic lymphocytic leukemia (CLL).

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