Alexa Fluor 488 anti-human/mouse/rat CD278 ICOS Antibody anti-CD278 - C398.4A,BioLegend,313514

The C398.4A antibody is useful for flow cytometric analysis and is able to costimulate T cell activation and proliferation. Additional reported applications (for the relevant formats) include: immunoprecipitation1,in vitrocostimulation of T cell activation1,3,4, and spatial biology (IBEX)5,6. The LEAF™ purified antibody (Endotoxin < 0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 313512).

Host

Armenian Hamster

Reactivity

Human, Mouse, Rat

Application

FC -Quality testedSB -Reported in the literature, not verified in house

Platform ID

BAB526115603

BioLegend

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Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NameAlexa Fluor 488 anti-human/mouse/rat CD278 ICOS Antibody anti-CD278 - C398.4A
Cat. No.313514
HostArmenian Hamster
RRIDAB_2122584 (BioLegend Cat. No. 313514)
IsotypeArmenian Hamster IgG
ReactivityHuman, Mouse, Rat
ApplicationFC -Quality testedSB -Reported in the literature, not verified in house
ClonalityMonoclonal
Clone NumberC398.4A
Concentration0.5 mg/ml
TargetCD278
ImmunogenMouse T cell clone D10.G4.1
PurityThe antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

ICOS, also known as inducible costimulatory molecule and H4, is a 47-57 kD protein. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS is involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7h/B7RP-1 or B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development.

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