Alexa Fluor® 568 Anti-AICDA antibody [EPR23436-45] - ChIP Grade,Abcam,AB312339

Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies . How are conjugated primary antibodies validated? This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling. For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

Host

Rabbit

Reactivity

Human

Application

Antibody Labelling, Flow Cyt (Intra), ICC/IF, Target Binding Affinity, IHC-P

Conjugate

Alexa Fluor® 568

Platform ID

BAB357206603

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAlexa Fluor® 568 Anti-AICDA antibody [EPR23436-45] - ChIP Grade
Cat. No.AB312339
HostRabbit
IsotypeIgG
ReactivityHuman
ConjugationAlexa Fluor® 568
ApplicationAntibody Labelling, Flow Cyt (Intra), ICC/IF, Target Binding Affinity, IHC-P
ClonalityMonoclonal
Clone NumberEPR23436-45
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed : 18722174, PubMed : 21385873, PubMed : 21518874, PubMed : 27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed : 21496894). See full target information AICDA

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