Alexa Fluor® 594 anti-HMB-45 Antibody, HMB-45, HMB-45,BioLegend,911507

Host

Mouse

Reactivity

Human

Application

IHC-P - Quality tested

Platform ID

BAB923392405

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

Email:

Product Specifications
Scientific Background

Specifications

NameAlexa Fluor® 594 anti-HMB-45 Antibody, HMB-45, HMB-45
Cat. No.911507
HostMouse
RRIDAB_2924625 (BioLegend Cat. No. 911507)AB_2924625 (BioLegend Cat. No. 911508)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationIHC-P - Quality tested
ClonalityMonoclonal
Clone NumberHMB-45
Concentration0.5 mg/mL
TargetHMB-45
ImmunogenThis antibody was developed using an extract of pigmented melanoma metastases from lymph nodes.
PurityThe antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 594 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

The HMB-45 antibody reacts with an intracytoplasmic antigen expressed by a majority of melanomas (melanotic and amelanotic) and other tumors expressing melanocytic differentiation. In general, epithelioid melanoma cells display more uniform staining than more sarcomatous spindle-shaped melanoma cells. Tumor cells of epithelial, lymphoid, glial and mesenchymal origin are negative. In normal cells, the antibody reacts with junctional and blue nevus cells and with fetal and neonatal melanocytes (variable). Intradermal nevi, non-melanocytic cells and normal adult melanocytes are negative.

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