Alexa Fluor 594 anti-mouse CD47 Antibody, CD47, miap301,BioLegend,127531

Additional reported applications (for the relevant formats) include: blocking2and immunohistochemical staining of frozen sections3. This clone is not cross-reactive with human CD47.

Host

Rat

Reactivity

Mouse

Application

IHC-F -Quality tested

Platform ID

BAB066446235

BioLegend

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Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NameAlexa Fluor 594 anti-mouse CD47 Antibody, CD47, miap301
Cat. No.127531
HostRat
RRIDAB_2783079 (BioLegend Cat. No. 127531)AB_2783080 (BioLegend Cat. No. 127532)
IsotypeRat IgG2a, κ
ReactivityMouse
ApplicationIHC-F -Quality tested
ClonalityMonoclonal
Clone Numbermiap301
Concentration0.5 mg/ml
TargetCD47
PurityThe antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 594 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD47, also known as Integrin-Associated Protein (IAP), is a membrane protein of about 50 kD with an IgV-like extracelluluar domain, a five membrane-spanning segment and a short terminal cytoplasmic region. It is widely expressed on many cell types and often associated with beta 3 integrins. It has been reported that CD47 functions as a self marker. Red cells lacking CD47 were rapidly cleared from the bloodstream by splenic macrophages. By binding to SIRPα, CD47 controls hemostatic innate immune functions, such as phagocytosis and cell trafficking.

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