Alexa Fluor 647 anti-SNAP-25 Antibody, SNAP-25, SMI 81,BioLegend,836312

Host

Mouse

Reactivity

Human, Mouse, Rat

Application

IHC-P -Quality tested

Platform ID

BAB765223305

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

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Product Specifications
Scientific Background

Specifications

NameAlexa Fluor 647 anti-SNAP-25 Antibody, SNAP-25, SMI 81
Cat. No.836312
HostMouse
RRIDAB_2820135 (BioLegend Cat. No. 836311)AB_2820136 (BioLegend Cat. No. 836312)
IsotypeMouse IgG1, κ
ReactivityHuman, Mouse, Rat
ApplicationIHC-P -Quality tested
ClonalityMonoclonal
Clone NumberSMI 81
Concentration0.5 mg/mL
TargetSNAP-25
ImmunogenFull length, unaltered SNAP-25
PurityThe antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

Synaptosomal-associated protein 25 (SNAP-25) is a component of the trans-SNARE (t-SNARE) complex. SNAP-25 has been reported to account for the specificity of membrane fusion, and to directly execute fusion by forming a tight complex that brings the synaptic vesicle and plasma membranes together. SNAP-25 has been shown to inhibits both ATP-dependent and independent Ca2+-triggered release of glutamate from central nervous system (CNS) synaptosomal membranes. This indicates that SNAP-25 has a role not only in the formation of the synaptic vesicle-target v- and t-SNARE complex, but also in the final neurotransmitter release.

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