Alexa Fluor 647 anti-STAT6 Phospho Tyr641 Antibody anti-STAT6 Phospho (Tyr641) - A15137E,BioLegend,686011

Human STAT6 has three isoforms; the molecular weights are 94, 82 and 74kD. The immunogen (phosphorylated peptide) is shared by these three isoforms. This antibody recognizes STAT6 Phospho (Tyr641) in all three isoforms. The predominant band detected is at 94 kD.Clone A15137E does not react with mouse.This clone is not recommended for ChIP (Chromatin Immunoprecipitation) assays (as determined by in-house testing).

Host

Mouse

Reactivity

Human

Application

ICFC - Quality tested

Platform ID

BAB047044288

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Product Specifications
Scientific Background

Specifications

NameAlexa Fluor 647 anti-STAT6 Phospho Tyr641 Antibody anti-STAT6 Phospho (Tyr641) - A15137E
Cat. No.686011
HostMouse
RRIDAB_2632684 (BioLegend Cat. No. 686011)AB_2632685 (BioLegend Cat. No. 686012)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationICFC - Quality tested
ClonalityMonoclonal
Clone NumberA15137E
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetSTAT6 Phospho Tyr641
ImmunogenHuman STAT6 peptide phosphorylated at Tyr 641
PurityThe antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

STAT6 is a member of the signal transducer and activator of transcription (STAT) family, activating gene expression in response to IL-4 and IL-13 stimulation. Upon cytokine stimulation, the receptor is phosphorylated by the associated Janus Kinases (Jak), followed by recruiting cytoplasmic STAT6. The Tyr641 residue of STAT6 is, in turn, phosphorylated by Jak. Phosphorylated STAT6 forms homodimers, translocates to the nucleus, and regulates transcription of target genes. STAT6 plays crucial roles in differentiation of T helper 2 (Th2) cells, class switch of immunoglobulins in B cells, expression of cell surface markers such as MHC class II, and the development of allergic inflammation.

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