Alexa Fluor® 647 anti-Synaptophysin Antibody, Synaptophysin, SP17,BioLegend,837106

SP17 reacts with native, denatured and recombinant synaptic vesicle protein synaptophysin expressed in CHO cells. The antibody is particularly valuable for immunocytochemical studies of the brain due to its stability in formalin sections.

Host

Mouse

Reactivity

Human, Mouse, Rat

Application

IHC-P - Quality tested

Platform ID

BAB905489738

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Product Specifications
Scientific Background

Specifications

NameAlexa Fluor® 647 anti-Synaptophysin Antibody, Synaptophysin, SP17
Cat. No.837106
HostMouse
RRIDAB_3662339 (BioLegend Cat. No. 837105)AB_3662339 (BioLegend Cat. No. 837106)
IsotypeMouse IgM, κ
ReactivityHuman, Mouse, Rat
ApplicationIHC-P - Quality tested
ClonalityMonoclonal
Clone NumberSP17
Concentration0.5 mg/mL
TargetSynaptophysin
ImmunogenThis antibody was raised against a crude synaptic preparation from post mortem human brain.
PurityThe antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

Synaptophysin, also known as major synaptic vesicle protein P38, is encoded by the SYP gene in humans and is located on the short arm of the X chromosome. Synaptophysin is expressed in neuroendocrine cells as well as all neurons in the CNS that participate in synaptic transmission. Synaptophysin is a synaptic vesicle glycoprotein, and interacts with synaptobrevin. It has been implicated in X-linked mental retardation and can be used as a specific marker for cells of the adrenal medulla and pancreatic islets. As such, it can be used to identify tumors that are derived from those cells, including neuroblastoma, retinoblastoma, medulloblastoma, and others.

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