Alexa Fluor® 647 anti-human CD339 (Jagged 1) Antibody, CD339, W16199B,BioLegend,399103

Host

Rat

Reactivity

Human

Application

FC - Quality tested

Platform ID

BAB766822537

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

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Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NameAlexa Fluor® 647 anti-human CD339 (Jagged 1) Antibody, CD339, W16199B
Cat. No.399103
HostRat
RRIDAB_2890847 (BioLegend Cat. No. 399103)AB_2890847 (BioLegend Cat. No. 399104)
IsotypeRat IgG2a, κ
ReactivityHuman
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberW16199B
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetCD339
ImmunogenHuman Jagged-transfected RBL1 cells
PurityThe antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD339, also known as Jagged 1, is a 135 kDa type 1 transmembrane protein with one DSL (Delta, Serrate, LagZ) domain, fifteen EGF-like domains, and one cysteine-rich region. Jagged 1 is expressed by many cell types including macrophages, subsets of dendritic cells, astrocytes, stromal, and epithelial cells. Jagged 1 regulates cell fate decisions in various tissues, and has an important role in neurogenesis and development of the cardiovascular system. Some studies suggest Jagged 1 is also involved in Th2 polarization and Treg induction.

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