Alexa Fluor 647 anti-mouse CD40 Antibody anti-CD40 - HM40-3,BioLegend,102911

Additional reported applications (for the relevant formats) include: blocking of CD40 ligand binding1, stimulation of mouse B cell and dendritic cell proliferation2-6,9, and immunohistochemistry7of acetone-fixed frozen sections. The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 102908).

Host

Armenian Hamster

Reactivity

Mouse

Application

FC -Quality tested

Platform ID

BAB672867657

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

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Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NameAlexa Fluor 647 anti-mouse CD40 Antibody anti-CD40 - HM40-3
Cat. No.102911
HostArmenian Hamster
RRIDAB_492855 (BioLegend Cat. No. 102911)AB_492854 (BioLegend Cat. No. 102912)
IsotypeArmenian Hamster IgM
ReactivityMouse
ApplicationFC -Quality tested
ClonalityMonoclonal
Clone NumberHM40-3
Concentration0.5 mg/ml
TargetCD40
Immunogen(BALB/c x NZB)F1mouse-derived lymphoma WEHI 231
PurityThe antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD40 is a 48 kD type I transmembrane glycoprotein, also known as Bp50. It is a member of the tumor necrosis factor receptor (TNFR) superfamily, expressed on B cells, basal epithelial cells, macrophages, follicular dendritic cells, endothelial cells, and a subset of CD34+hematopoietic progenitors. CD40 regulates B cell development/maturation, Ig isotype switching and, in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with its ligand CD154 (gp39) expressed on activated T cells, is important in costimulation and immune regulation. The HM40-3 antibody has been reported to stimulate dendritic and B cell proliferation and block CD40-CD40L interactions.

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