Alexa Fluor 647 anti-mouse CD85k gp49 Receptor Antibody anti-CD85k - H1.1,BioLegend,144905

Clone H1.1 recognizes both gp49A and gp49B. Additional reported applications (for the relevant formats) includein vitroactivation of gp49B to inhibit cytokine production. The LEAF™ or Ultra-LEAF™ purified antibody is recommended for functional assays (contact ourcustom solutions team).

Host

Armenian Hamster

Reactivity

Mouse

Application

FC - Quality tested

Platform ID

BAB976378224

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Product Specifications
Scientific Background

Specifications

NameAlexa Fluor 647 anti-mouse CD85k gp49 Receptor Antibody anti-CD85k - H1.1
Cat. No.144905
HostArmenian Hamster
RRIDAB_2562043 (BioLegend Cat. No. 144905)AB_2562044 (BioLegend Cat. No. 144906)
IsotypeArmenian Hamster IgG
ReactivityMouse
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberH1.1
Concentration0.5 mg/ml
TargetCD85k
Immunogengp49B-Fc fusion protein
PurityThe antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

gp49, also known as ILT3, gp49b1 or CD85k, is a 49 kD glycoprotein expressed on activated NK cells and myeloid cells. It structurally resembles killer inhibitory receptors (KIR). gp49B is a type I membrane protein belonging to the Ig superfamily and contains an immunoreceptor tyrosine-based inhibitory motif (ITIM), while gp49A is a truncated molecule without ITIM. Upon activation following interaction with integrin avb3, the cytoplasmic tail associates with SHP-1 and SHP-2, which results in downregulation of cell activation and cytokine production.

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