Alexa Fluor 647 anti-mouse IL-17RB Antibody anti-IL-17RB - 9B10,BioLegend,146303

Host

Rat

Reactivity

Mouse

Application

FC - Quality tested

Platform ID

BAB699566100

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

Email:

Product Specifications
Scientific Background

Specifications

NameAlexa Fluor 647 anti-mouse IL-17RB Antibody anti-IL-17RB - 9B10
Cat. No.146303
HostRat
RRIDAB_2562380 (BioLegend Cat. No. 146303)AB_2562381 (BioLegend Cat. No. 146304)
IsotypeRat IgG2a, κ
ReactivityMouse
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone Number9B10
Concentration0.5 mg/ml
TargetIL-17RB
ImmunogenRecombinant mouse IL-17RB - Fc chimera (human IgG1)
PurityThe antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

IL-17RB, also known as IL17RH1, belongs to the cytokine receptor family.  IL-17RB possesses a unique intracellular signaling molecule called SEFIR, and is expressed similarily to fibroblast growth factor genes and IL-17R.  It is reported to be expressed on iNKT cells, innate lymphoid cells (ILC), and Th2 cells.  It binds IL-17B and IL-17E (IL-25) but not IL-17A or C.  Its interaction with IL-25 has a higher affinity than that with IL-17B.  Binding of IL-17RB and IL-25/IL-17E induces NF-kB mediated IL-8 production through interaction with TRAF6 and Act1.  IL-17RB has been reported to play a role in autoimmune diseases such as rheumatoid arthritis and asthma.

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.