Alexa Fluor 647 anti-mouse/rat CD61 Antibody anti-CD61 - 2C9.G2 (HMß3-1),BioLegend,104314

The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 104325 and 104326).

Host

Armenian Hamster

Reactivity

Mouse, Rat

Application

FC - Quality tested

Platform ID

BAB738758543

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

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Product Specifications
Scientific Background

Specifications

NameAlexa Fluor 647 anti-mouse/rat CD61 Antibody anti-CD61 - 2C9.G2 (HMß3-1)
Cat. No.104314
HostArmenian Hamster
RRIDAB_2249337 (BioLegend Cat. No. 104313)AB_2234024 (BioLegend Cat. No. 104314)
IsotypeArmenian Hamster IgG
ReactivityMouse, Rat
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone Number2C9.G2 (HMβ3-1)
Concentration0.5 mg/mL
TargetCD61
ImmunogenVitronectin receptor protein from the mouse T-cell hybridoma 2B4.
PurityThe antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD61 is a 110 kD integrin β chain also known as β3integrin or gpIIIa. It associates with the integrin αvchain (CD51) to form the vitronectin receptor. In addition, CD61 can associate with the integrin αIIbchain (CD41) to form the gpIIb/IIIa complex. CD61 is expressed on platelets, megakaryocytes, endothelium, smooth muscle, a subset of B cells, myeloid cells, osteoclasts, and mast cells. CD61, in conjunction with CD41 or CD51, mediates adhesion to fibronectin, fibrinogen, vitronectin, thrombospondin, and von Willebrand factor. Leukocyte-endothelial adhesion is mediated by the binding of αv/β3integrin or vitronectin receptor to CD31 (PECAM-1).

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