Alexa Fluor 700 anti-human CD11aCD18 LFA-1 Antibody, CD18, m24,BioLegend,363421

Clone m24 can be used as a reporter of the activation state of integrin receptor in response to exposure with Mg2+or Mn2+.

Host

Mouse

Reactivity

Human

Application

FC -Quality tested

Platform ID

BAB435836429

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Headquarters

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Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NameAlexa Fluor 700 anti-human CD11aCD18 LFA-1 Antibody, CD18, m24
Cat. No.363421
HostMouse
RRIDAB_2810573 (BioLegend Cat. No. 363421)AB_2810574 (BioLegend Cat. No. 363422)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationFC -Quality tested
ClonalityMonoclonal
Clone Numberm24
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetCD11a or CD18
ImmunogenFibronectin-purified human monocytes
PurityThe antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 700 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD11/CD18 belongs to the integrin family of proteins. It is heterodimeric cell surface receptor expressed on all leukocytes. CD18, in association with integrin α chain CD11a, CD11b, and CD11c forms LFA-1, Mac-1, and αXβ2, respectively, and plays an important role in leukocyte adhesion. CD11/CD18 complexes bind ICAM-1 (CD54), ICAM-2 (CD102), ICAM-3 (CD50), iC3b, and fibrinogen. Clone m24 binds the extended/open high affinity conformation of CD11a/CD18. The antibody can be used as a reporter of the activation state of the integrin receptor in response to exposure to Mg2+or Mn2+.

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