Alexa Fluor 700 anti-mouse TCR beta chain Antibody anti-TCR beta chain - H57-597,BioLegend,109224
H57-597 is a hamster mAb directed to an epitope of the C region of TCR ß chain12. The H57-597 antibody does not cross-react with ?/d TCR-bearing T cells. Immobilized or soluble H57-597 antibody can activate a/ß TCR-bearing T cells. Additional reported applications (for the relevant formats) for this antibody include: immunoprecipitation2,in vitrostimulation2,3,in vivodepletion4-6, and immunohistochemical staining of acetone-fixed frozen sections7,8,9. The Ultra-LEAF™ purified antibody (Endotoxin <0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 109253-109258).
Host
Armenian Hamster
Reactivity
Mouse
Application
FC - Quality tested
Platform ID
BAB102840022
BioLegend
Contact
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Product Specifications
Scientific Background
Specifications
NameAlexa Fluor 700 anti-mouse TCR beta chain Antibody anti-TCR beta chain - H57-597
Cat. No.109224
HostArmenian Hamster
RRIDAB_1027654 (BioLegend Cat. No. 109223)AB_1027648 (BioLegend Cat. No. 109224)
IsotypeArmenian Hamster IgG
ReactivityMouse
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberH57-597
Concentration0.5 mg/ml
TargetTCR beta chain
ImmunogenAffinity purified TCR from mouse DO-11.10 cells
PurityThe antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 700 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only
Scientific Background
T cell receptor (TCR) is a heterodimer consisting of an α and a β chain (TCR α/β) or a γ and a δ chain (TCR γ/δ). TCR-β is a member of the immunoglobulin superfamily and a component of the CD3/TCR complex (along with TCR-α). It is expressed on α/β TCR-bearing T cells and thymocytes. The CD3/TCR complex plays a key role in antigen recognition, signal transduction, and T cell activation.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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